Sodium tanshinone IIA sulfonate protects rat myocardium against ischemia-reperfusion injury via activation of PI3K/Akt/FOXO3A/Bim pathway

AIM: To investigate the mechanisms underlying the protective effects of sodium tanshinone IIA sulfonate (STS) in an ischemia-reperfusion (I/R)-induced rat myocardial injury model. METHODS: Male SD rats were iv injected with STS, STS+LY294002 or saline (NS) for 15 d. Then the hearts were subjected to...

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Autors principals: Zhang, Mei-qi, Zheng, Yue-liang, Chen, Huan, Tu, Jian-feng, Shen, Ye, Guo, Jun-ping, Yang, Xiang-hong, Yuan, Shu-ren, Chen, Liang-zhong, Chai, Jing-jie, Lu, Jian-hong, Zhai, Chang-lin
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2013
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4006464/
https://ncbi.nlm.nih.gov/pubmed/24077633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2013.91
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