Comparative study of in vitro release and mucoadhesivity of gastric compacts composed of multiple unit system/bilayered discs using direct compression of metformin hydrochloride

Introduction: Metformin is an oral anti-diabetic drug in the biguanide class. The goal of this study was to develop gastric-retentive MH discs in order to prolong the retention of drug in gastric mucosa. Methods: Two groups of metformin hydrochloride (MH) mucoadhesive gastroretentive discs were prep...

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Autors principals: Jelvehgari, Mitra, Zakeri-Milani, Parvin, Khonsari, Fatemeh
Format: Artigo
Idioma:Inglês
Publicat: Tabriz University of Medical Sciences 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4005280/
https://ncbi.nlm.nih.gov/pubmed/24790896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5681/bi.2014.002
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