A DNA break– and phosphorylation-dependent positive feedback loop promotes immunoglobulin class-switch recombination

The ability of activation-induced cytidine deaminase (AID) to efficiently mediate class-switch recombination (CSR) is dependent on its phosphorylation at Ser38; however, the trigger that induces AID phosphorylation and the mechanism by which phosphorylated AID drives CSR have not been elucidated. He...

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Detalhes bibliográficos
Main Authors: Vuong, Bao Q, Herrick-Reynolds, Kayleigh, Vaidyanathan, Bharat, Pucella, Joseph N, Ucher, Anna J, Donghia, Nina M, Gu, Xiwen, Nicolas, Laura, Nowak, Urszula, Rahman, Numa, Strout, Matthew P, Mills, Kevin D, Stavnezer, Janet, Chaudhuri, Jayanta
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4005274/
https://ncbi.nlm.nih.gov/pubmed/24097111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2732
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