Follistatin-like protein 1 enhances NLRP3 inflammasome-mediated IL-1β secretion from monocytes and macrophages

Follistatin-like protein 1 (FSTL-1) is overexpressed in a number of inflammatory conditions characterized by elevated IL-1β. Here we found that FSTL-1 serum concentration was increased three-fold in patients with bacterial sepsis and four-fold following administration of endotoxin (LPS) to mice. To...

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Detalhes bibliográficos
Main Authors: Chaly, Yury, Fu, Yu, Marinov, Anthony, Hostager, Bruce, Yan, Wei, Campfield, Brian, Kellum, John A., Bushnell, Daniel, Wang, Yudong, Vockley, Jerry, Hirsch, Raphael
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4004659/
https://ncbi.nlm.nih.gov/pubmed/24470197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201344063
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