Nonenzymatic domains of Kalirin7 contribute to spine morphogenesis through interactions with phosphoinositides and Abl

Like several Rho GDP/GTP exchange factors (GEFs), Kalirin7 (Kal7) contains an N-terminal Sec14 domain and multiple spectrin repeats. A natural splice variant of Kalrn lacking the Sec14 domain and four spectrin repeats is unable to increase spine formation; our goal was to understand the function of...

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Hlavní autoři: Ma, Xin-Ming, Miller, Megan B., Vishwanatha, K. S., Gross, Maegan J., Wang, Yanping, Abbott, Thomas, Lam, TuKiet T., Mains, Richard E., Eipper, Betty A.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Cell Biology 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4004595/
https://ncbi.nlm.nih.gov/pubmed/24600045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E13-04-0215
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