The Retromer Complex Is Required for Rhodopsin Recycling and Its Loss Leads to Photoreceptor Degeneration

Rhodopsin mistrafficking can cause photoreceptor (PR) degeneration. Upon light exposure, activated rhodopsin 1 (Rh1) in Drosophila PRs is internalized via endocytosis and degraded in lysosomes. Whether internalized Rh1 can be recycled is unknown. Here, we show that the retromer complex is expressed...

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Detalhes bibliográficos
Main Authors: Wang, Shiuan, Tan, Kai Li, Agosto, Melina A., Xiong, Bo, Yamamoto, Shinya, Sandoval, Hector, Jaiswal, Manish, Bayat, Vafa, Zhang, Ke, Charng, Wu-Lin, David, Gabriela, Duraine, Lita, Venkatachalam, Kartik, Wensel, Theodore G., Bellen, Hugo J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4004542/
https://ncbi.nlm.nih.gov/pubmed/24781186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1001847
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