Transformation of Plasmodium falciparum malaria parasites by homologous integration of plasmids that confer resistance to pyrimethamine.

Plasmodium falciparum malaria parasites were transformed with plasmids containing P. falciparum or Toxoplasma gondii dihydrofolate reductase-thymidylate synthase (dhfr-ts) coding sequences that confer resistance to pyrimethamine. Under pyrimethamine pressure, transformed parasites were obtained that...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Wu, Y, Kirkman, L A, Wellems, T E
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1996
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40043/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8577727/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.3.1130
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