EDD enhances cell survival and cisplatin resistance and is a therapeutic target for epithelial ovarian cancer

The E3 ubiquitin ligase EDD is overexpressed in recurrent, platinum-resistant ovarian cancers, suggesting a role in tumor survival and/or platinum resistance. EDD knockdown by small interfering RNA (siRNA) induced apoptosis in A2780ip2, OVCAR5 and ES-2 ovarian cancer cells, correlating with loss of...

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Bibliographische Detailangaben
Hauptverfasser: Bradley, Amber, Zheng, Hui, Ziebarth, Angela, Sakati, Wayne, Branham-O’Connor, Melissa, Blumer, Joe B., Liu, Yuying, Kistner-Griffin, Emily, Rodriguez-Aguayo, Cristian, Lopez-Berestein, Gabriel, Sood, Anil K., Landen, Charles N., Eblen, Scott T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2014
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Original Manuscript
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4004201/
https://ncbi.nlm.nih.gov/pubmed/24379240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgt489
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