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Using a large-scale knowledge database on reactions and regulations to propose key upstream regulators of various sets of molecules participating in cell metabolism

BACKGROUND: Most of the existing methods to analyze high-throughput data are based on gene ontology principles, providing information on the main functions and biological processes. However, these methods do not indicate the regulations behind the biological pathways. A critical point in this contex...

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Detalhes bibliográficos
Main Authors: Blavy, Pierre, Gondret, Florence, Lagarrigue, Sandrine, van Milgen, Jaap, Siegel, Anne
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4004165/
https://ncbi.nlm.nih.gov/pubmed/24635915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1752-0509-8-32
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