Estimation of malaria haplotype and genotype frequencies: a statistical approach to overcome the challenge associated with multiclonal infections

BACKGROUND: Reliable measures of anti-malarial resistance are crucial for malaria control. Resistance is typically a complex trait: multiple mutations in a single parasite (a haplotype or genotype) are necessary for elaboration of the resistant phenotype. The frequency of a genetic motif (proportion...

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Bibliographische Detailangaben
Hauptverfasser: Taylor, Aimee R, Flegg, Jennifer A, Nsobya, Samuel L, Yeka, Adoke, Kamya, Moses R, Rosenthal, Philip J, Dorsey, Grant, Sibley, Carol H, Guerin, Philippe J, Holmes, Chris C
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2014
Schlagworte:
Methodology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4004158/
https://ncbi.nlm.nih.gov/pubmed/24636676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2875-13-102
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