Metabolic flux responses to genetic modification for shikimic acid production by Bacillus subtilis strains

BACKGROUND: Shikimic acid (SA) is a key chiral starting molecule for the synthesis of the neuramidase inhibitor GS4104 against viral influenza. Microbial production of SA has been extensively investigated in Escherichia coli, and to a less extent in Bacillus subtilis. However, metabolic flux of the...

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Detalhes bibliográficos
Principais autores: Liu, Dong-Feng, Ai, Guo-Min, Zheng, Qing-Xiang, Liu, Chang, Jiang, Cheng-Ying, Liu, Li-Xia, Zhang, Bo, Liu, Yi-Ming, Yang, Chen, Liu, Shuang-Jiang
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4003833/
https://ncbi.nlm.nih.gov/pubmed/24628944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2859-13-40
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