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Treatment of Transmissible Spongiform Encephalopathy by Intraventricular Drug Infusion in Animal Models
The therapeutic efficacy of direct drug infusion into the brain, the target organ of transmissible spongiform encephalopathies, was assessed in transgenic mice intracerebrally infected with 263K scrapie agent. Pentosan polysulfate (PPS) gave the most dramatic prolongation of the incubation period, a...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC400350/ https://ncbi.nlm.nih.gov/pubmed/15113880 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.10.4999-5006.2004 |
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