Identification of Unique Hepatitis C Virus Quasispecies in the Central Nervous System and Comparative Analysis of Internal Translational Efficiency of Brain, Liver, and Serum Variants

Reports of cerebral dysfunction in chronic hepatitis C virus (HCV) infection have led to the suggestion that HCV may infect the central nervous system (CNS). We used reverse transcription-PCR, cloning, and sequencing to define quasispecies for the HCV internal ribosomal entry site (IRES) and hyperva...

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Bibliographische Detailangaben
Hauptverfasser: Forton, Daniel M., Karayiannis, Peter, Mahmud, Nadiya, Taylor-Robinson, Simon D., Thomas, Howard C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2004
Schlagworte:
Pathogenesis and Immunity
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC400349/
https://ncbi.nlm.nih.gov/pubmed/15113899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.10.5170-5183.2004
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