HPLC and LC-MS analysis of sinomenine and its application in pharmacokinetic studies in rats

AIM: To improve and validate analytical methods based on HPLC and liquid chromatography coupled to electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) for the quantitative measurement of sinomenine in rat plasma and brain tissue. METHODS: The separation of analytes and the internal stand...

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Autores principales: Long, Li-hong, Wu, Peng-fei, Chen, Xiang-long, Zhang, Zui, Chen, Yu, Li, Yi-yong, Jin, You, Chen, Jian-guo, Wang, Fang
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2010
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4003331/
https://ncbi.nlm.nih.gov/pubmed/20871622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2010.122
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