Emodin induces human T cell apoptosis in vitro by ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction

AIM: To elucidate the molecular mechanisms underlying the immunosuppressive effects of emodin isolated from Rheum palmatum L. METHODS: Human T cells were isolated from the peripheral venous blood of 10 healthy adult donors. Cell viability was analyzed with MTT assay. AO/EB and Annexin V/PI staining...

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Main Authors: Qu, Kai, Shen, Nai-ying, Xu, Xin-sen, Su, Hai-bo, Wei, Ji-chao, Tai, Ming-hui, Meng, Fan-di, Zhou, Lei, Zhang, Yue-lang, Liu, Chang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4003158/
https://ncbi.nlm.nih.gov/pubmed/23811723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2013.58
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