Effects of ticlopidine on pharmacokinetics of losartan and its main metabolite EXP-3174 in rats

AIM: Losartan and antiplatelet agent ticlopidine can be prescribed concomitantly for prevention or therapy of cardiovascular diseases. Hence, the effects of ticlopidine on the pharmacokinetics of losartan and its active metabolite EXP-3174 were evaluated in rats. METHODS: Ticlopidine (4 or 10 mg/kg...

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Bibliografske podrobnosti
Main Authors: Yang, Si-hyung, Cho, Young-ah, Choi, Jun-shik
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2011
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4003123/
https://ncbi.nlm.nih.gov/pubmed/21666702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2011.32
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