Discovery of N-(3,5-bis(1-pyrrolidylmethyl)-4-hydroxybenzyl)-4-methoxybenzenesulfamide (sulcardine) as a novel anti-arrhythmic agent

AIM: To investigate the anti-arrhythmic effects of sulfamide analogues of changrolin and to characterize the sulfate of compound 6f (sulcardine sulfate, Sul) as a novel anti-arrhythmic agent. METHODS: The anti-arrhythmic effects of compounds were studied against aconitine-induced arrhythmias in rats...

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Detalhes bibliográficos
Main Authors: Bai, Dong-lu, Chen, Wei-zhou, Bo, Yun-xin, Dong, Yue-li, Kang, Ai-li, Sun, Wei-kang, Wang, Wei, Hu, Zhong-liang, Wang, Yi-ping
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4003109/
https://ncbi.nlm.nih.gov/pubmed/22922342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2012.119
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