Enhancement of oral bioavailability of the poorly water-soluble drug silybin by sodium cholate/phospholipid-mixed micelles

AIM: To evaluate a mixed micellar drug delivery system composed of sodium cholate and phospholipid for oral administration of silybin, a promising hepatoprotectants. METHODS: The optimum formulation of sodium cholate/phospholipid-mixed micelles containing silybin was obtained based on the study of p...

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Main Authors: Yu, Jiang-nan, Zhu, Yuan, Wang, Li, Peng, Min, Tong, Shan-shan, Cao, Xia, Qiu, Hui, Xu, Xi-ming
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4002977/
https://ncbi.nlm.nih.gov/pubmed/20523347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2010.55
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