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Addictive evaluation of cholic acid-verticinone ester, a potential cough therapeutic agent with agonist action of opioid receptor

AIM: The purpose of this work was to search for potential drugs with potent antitussive and expectorant activities as well as a low toxicity, but without addictive properties. Cholic acid-verticinone ester (CA-Ver) was synthesized based on the clearly elucidated antitussive and expectorant activitie...

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Detalhes bibliográficos
Main Authors: Zhang, Jiu-liang, Wang, Hui, Chen, Chang, Pi, Hui-fang, Raun, Han-li, Zhang, Peng, Wu, Ji-zhou
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4002828/
https://ncbi.nlm.nih.gov/pubmed/19417735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2009.43
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