Knock-down of protein L-isoaspartyl O-methyltransferase increases β-amyloid production by decreasing ADAM10 and ADAM17 levels

AIM: To examine the role of protein L-isoaspartyl O-methyltransferase (PIMT; EC 2.1.1.77) on the secretion of Aβ peptides. METHODS: HEK293 APPsw cells were treated with PIMT siRNA or adenosine dialdehyde (AdOX), a broad-spectrum methyltransferase inhibitor. Under the conditions, the level of Aβ secr...

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Detalhes bibliográficos
Main Authors: Bae, Narkhyun, Byeon, Se Eun, Song, Jihyuk, Lee, Sang-Jin, Kwon, Moosik, Mook-Jung, Inhee, Cho, Jae Youl, Hong, Sungyoul
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4002779/
https://ncbi.nlm.nih.gov/pubmed/21372823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2010.228
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