Dexmedetomidine blocks thermal hyperalgesia and spinal glial activation in rat model of monoarthritis

AIM: To investigate the effect of systemic administration dexmedetomidine, a selective alpha 2 adrenergic receptor (α(2)AR) agonist, on thermal hyperalgesia and spinal glial activation evoked by monoarthritis (MA). METHODS: MA was induced by an intra-articular injection of complete Freund's adj...

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Main Authors: Xu, Bo, Zhang, Wei-shi, Yang, Jia-le, Xu, Hua, Deng, Xiao-ming, Zhang, Yu-qiu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4002747/
https://ncbi.nlm.nih.gov/pubmed/20364156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2010.32
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