Luteolin reduces the invasive potential of malignant melanoma cells by targeting β3 integrin and the epithelial-mesenchymal transition

AIM: To investigate whether luteolin, a highly prevalent flavonoid, reverses the effects of epithelial-mesenchymal transition (EMT) in vitro and in vivo and to determine the mechanisms underlying this reversal. METHODS: Murine malignant melanoma B16F10 cells were exposed to 1% O(2) for 24 h. Cellula...

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Main Authors: Ruan, Jun-shan, Liu, Yu-ping, Zhang, Lei, Yan, Ling-geng, Fan, Fang-tian, Shen, Cun-si, Wang, Ai-yun, Zheng, Shi-zhong, Wang, Shao-ming, Lu, Yin
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2012
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4002713/
https://ncbi.nlm.nih.gov/pubmed/22983392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2012.93
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