The chimeric genes AML1/MDS1 and AML1/EAP inhibit AML1B activation at the CSF1R promoter, but only AML1/MDS1 has tumor-promoter properties.

The (3;21)(q26;q22) translocation associated with treatment-related myelodysplastic syndrome, treatment-related acute myeloid leukemia, and blast crisis of chronic myeloid leukemia results in the expression of the chimeric genes AML1/EAP, AML1/MDS1, and AML1/EVI1. AML1 (CBFA2), which codes for the a...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Zent, C S, Mathieu, C, Claxton, D F, Zhang, D E, Tenen, D G, Rowley, J D, Nucifora, G
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1996
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40027/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8577711/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.3.1044
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