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PIK3CA hypomethylation plays a key role in activation of the PI3K/AKT pathway in esophageal cancer in Chinese patients

AIM: To investigate the role of PIK3CA oncogene in tumorigenesis and development of esophageal cancer in Chinese patients at the levels of genetic mutation and epigenetics. METHODS: Seventy six esophageal tumor samples and corresponding adjacent normal tissues were collected, and the genomic DNA was...

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Detalhes bibliográficos
Main Authors: Wang, Wei-feng, Xie, Yan, Zhou, Zhi-hua, Qin, Zheng-hong, Wu, Jun-chao, He, Jing-kang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4002570/
https://ncbi.nlm.nih.gov/pubmed/24241346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2013.163
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