Sphingosine-1-phosphate induces VEGF-C expression through a MMP-2/FGF-1/FGFR-1-dependent pathway in endothelial cells in vitro

AIM: To investigate whether sphingosine-1-phosphate (S1P), a potent angiogenic factor, induced vascular endothelial growth factor-C (VEGF-C) expression in endothelial cells in vitro and to examine its underlying mechanisms. METHODS: Human umbilical vein endothelial cells (HUVECs) were examined. VEGF...

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Detalhes bibliográficos
Main Authors: Chang, Chi-hao, Huang, Yuan-li, Shyu, Ming-kwang, Chen, Shee-uan, Lin, Chih-hsin, Ju, Tsai-kai, Lu, JenHer, Lee, Hsinyu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4002496/
https://ncbi.nlm.nih.gov/pubmed/23377549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2012.186
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