Marginal zone B cells are naturally reactive to collagen type II and are involved in the initiation of the immune response in collagen-induced arthritis

Antibodies against type II collagen (CII) are essential for development of collagen-induced arthritis (CIA), but how and where the B-cell response to CII is initiated is not fully known. We show here that naive DBA/1 mice display naturally reactive IgM and IgG anti-CII producing B cells prior to imm...

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Detalhes bibliográficos
Main Authors: Carnrot, Cecilia, Prokopec, Kajsa E, Råsbo, Kristina, Karlsson, Mikael CI, Kleinau, Sandra
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4002445/
https://ncbi.nlm.nih.gov/pubmed/21358667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cmi.2011.2
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