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Pharmacological tools for lysophospholipid GPCRs: development of agonists and antagonists for LPA and S1P receptors

Previous studies on lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) using various approaches have shown that both the molecules can act as intercellular signaling molecules. The discovery of the Edg subfamily of G-protein-coupled receptors (GPCRs) (later renamed LPA(1–3) and S1P(1–5))...

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Auteur principal: Im, Dong-Soon
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4002311/
https://ncbi.nlm.nih.gov/pubmed/20729877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2010.135
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