ACE2 deficiency increases NADPH‐mediated oxidative stress in the kidney

Angiotensin‐converting enzyme 2 (ACE2) is highly expressed in the kidney and hydrolyzes angiotensin II (Ang II) to Ang(1–7). Since Ang II is a strong activator of oxidative stress, we reasoned that ACE2 could be involved in the regulation of renal oxidative stress by governing the levels of Ang II....

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Autors principals: Wysocki, Jan, Ortiz‐Melo, David I., Mattocks, Natalie K., Xu, Katherine, Prescott, Jessica, Evora, Karla, Ye, Minghao, Sparks, Matthew A., Haque, Syed K., Batlle, Daniel, Gurley, Susan B.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2014
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4002244/
https://ncbi.nlm.nih.gov/pubmed/24760518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/phy2.264
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