Pharmacokinetic interactions between 20(S)-ginsenoside Rh2 and the HIV protease inhibitor ritonavir in vitro and in vivo

AIM: 20(S)-Ginsenoside Rh2 (Rh2) has shown potent inhibition on P-glycoprotein (P-gp), while most HIV protease inhibitors are both substrates and inhibitors of P-gp and CYP3A4. The aim of this study was to investigate the potential pharmacokinetic interactions between Rh2 and the HIV protease inhibi...

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Autori principali: Shi, Jian, Cao, Bei, Zha, Wei-bin, Wu, Xiao-lan, Liu, Lin-sheng, Xiao, Wen-jing, Gu, Rong-rong, Sun, Run-bin, Yu, Xiao-yi, Zheng, Tian, Li, Meng-jie, Wang, Xin-wen, Zhou, Jun, Mao, Yong, Ge, Chun, Ma, Ting, Xia, Wen-juan, Aa, Ji-ye, Wang, Guang-ji, Liu, Chang-xiao
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2013
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4002158/
https://ncbi.nlm.nih.gov/pubmed/23892274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2013.69
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