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Modulation of Mannose and Asialoglycoprotein Receptor Expression Determines Glycoprotein Hormone Half-life at Critical Points in the Reproductive Cycle

The rate at which glycoproteins are cleared from the circulation has a critical impact on their biologic activity in vivo. We have shown that clearance rates for glycoproteins such as luteinizing hormone (LH) that undergo regulated release into the circulation determine their potency. Two highly abu...

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Autori principali: Mi, Yiling, Lin, Angela, Fiete, Dorothy, Steirer, Lindsay, Baenziger, Jacques U.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4002119/
https://ncbi.nlm.nih.gov/pubmed/24619407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.544973
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