The Lantibiotic NAI-107 Binds to Bactoprenol-bound Cell Wall Precursors and Impairs Membrane Functions

The lantibiotic NAI-107 is active against Gram-positive bacteria including vancomycin-resistant enterococci and methicillin-resistant Staphylococcus aureus. To identify the molecular basis of its potency, we studied the mode of action in a series of whole cell and in vitro assays and analyzed struct...

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Detalhes bibliográficos
Main Authors: Münch, Daniela, Müller, Anna, Schneider, Tanja, Kohl, Bastian, Wenzel, Michaela, Bandow, Julia Elisabeth, Maffioli, Sonia, Sosio, Margherita, Donadio, Stefano, Wimmer, Reinhard, Sahl, Hans-Georg
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4002112/
https://ncbi.nlm.nih.gov/pubmed/24627484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.537449
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