Dopamine D2 Receptor Relies upon PPM/PP2C Protein Phosphatases to Dephosphorylate Huntingtin Protein

Striatal dopamine D2 receptor (D2R) relies upon G protein- and β-arrestin-dependent signaling pathways to convey its action on motor control and behavior. Considering that D2R activation inhibits Akt in the striatum and that huntingtin physiological functions are affected by Akt phosphorylation, we...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Marion, Sébastien, Urs, Nikhil M., Peterson, Sean M., Sotnikova, Tatyana D., Beaulieu, Jean-Martin, Gainetdinov, Raul R., Caron, Marc G.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4002081/
https://ncbi.nlm.nih.gov/pubmed/24619418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.544312
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares