Transporters MCT8 and OATP1C1 maintain murine brain thyroid hormone homeostasis

Allan-Herndon-Dudley syndrome (AHDS), a severe form of psychomotor retardation with abnormal thyroid hormone (TH) parameters, is linked to mutations in the TH-specific monocarboxylate transporter MCT8. In mice, deletion of Mct8 (Mct8 KO) faithfully replicates AHDS-associated endocrine abnormalities;...

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Detalhes bibliográficos
Main Authors: Mayerl, Steffen, Müller, Julia, Bauer, Reinhard, Richert, Sarah, Kassmann, Celia M., Darras, Veerle M., Buder, Katrin, Boelen, Anita, Visser, Theo J., Heuer, Heike
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4001533/
https://ncbi.nlm.nih.gov/pubmed/24691440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI70324
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