Identification of ML-9 as a lysosomotropic agent targeting autophagy and cell death

The growing number of studies suggested that inhibition of autophagy enhances the efficacy of Akt kinase inhibitors in cancer therapy. Here, we provide evidence that ML-9, a widely used inhibitor of Akt kinase, myosin light-chain kinase (MLCK) and stromal interaction molecule 1 (STIM1), represents t...

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Hauptverfasser: Kondratskyi, A, Yassine, M, Slomianny, C, Kondratska, K, Gordienko, D, Dewailly, E, Lehen'kyi, V, Skryma, R, Prevarskaya, N
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2014
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4001310/
https://ncbi.nlm.nih.gov/pubmed/24763050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.156
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