Identification of ML-9 as a lysosomotropic agent targeting autophagy and cell death

The growing number of studies suggested that inhibition of autophagy enhances the efficacy of Akt kinase inhibitors in cancer therapy. Here, we provide evidence that ML-9, a widely used inhibitor of Akt kinase, myosin light-chain kinase (MLCK) and stromal interaction molecule 1 (STIM1), represents t...

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Main Authors: Kondratskyi, A, Yassine, M, Slomianny, C, Kondratska, K, Gordienko, D, Dewailly, E, Lehen'kyi, V, Skryma, R, Prevarskaya, N
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2014
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4001310/
https://ncbi.nlm.nih.gov/pubmed/24763050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.156
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