Tumor necrosis factor receptor superfamily costimulation couples T cell receptor signal strength to thymic regulatory T cell differentiation

Regulatory T (T(reg)) cells express tumor necrosis factor receptor superfamily (TNFRSF) members, but their role in thymic T(reg) development is undefined. We demonstrate that T(reg) progenitors highly express the TNFRSF members GITR, OX40, and TNFR2. Expression of these receptors correlates directly...

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Hauptverfasser: Mahmud, Shawn A., Manlove, Luke S., Schmitz, Heather M., Xing, Yan, Wang, Yanyan, Owen, David L., Schenkel, Jason M., Boomer, Jonathan S., Green, Jonathan M., Yagita, Hideo, Chi, Hongbo, Hogquist, Kristin A., Farrar, Michael A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4000541/
https://ncbi.nlm.nih.gov/pubmed/24633226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2849
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