DYX1C1 is required for axonemal dynein assembly and ciliary motility

Dyx1c1 has been associated with dyslexia and neuronal migration in the developing neocortex. Unexpectedly, we found that deletion of Dyx1c1 exons 2–4 in mice caused a phenotype resembling primary ciliary dyskinesia (PCD), a genetically heterogeneous disorder characterized by chronic airway disease,...

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Autores principales: Tarkar, Aarti, Loges, Niki T., Slagle, Christopher E., Francis, Richard, Dougherty, Gerard W., Tamayo, Joel V., Shook, Brett, Cantino, Marie, Schwartz, Daniel, Jahnke, Charlotte, Olbrich, Heike, Werner, Claudius, Raidt, Johanna, Pennekamp, Petra, Abouhamed, Marouan, Hjeij, Rim, Köhler, Gabriele, Griese, Matthias, Li, You, Lemke, Kristi, Klena, Nikolas, Liu, Xiaoqin, Gabriel, George, Tobita, Kimimasa, Jaspers, Martine, Morgan, Lucy C., Shapiro, Adam J., Letteboer, Stef J.F., Mans, Dorus A., Carson, Johnny L., Leigh, Margaret W., Wolf, Whitney E., Chen, Serafine, Lucas, Jane S., Onoufriadis, Alexandros, Plagnol, Vincent, Schmidts, Miriam, Boldt, Karsten, Roepman, Ronald, Zariwala, Maimoona, Lo, Cecilia W., Mitchison, Hannah M., Knowles, Michael R., Burdine, Rebecca D., LoTurco, Joseph J., Omran, Heymut
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4000444/
https://ncbi.nlm.nih.gov/pubmed/23872636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2707
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