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Influenza virus A M2 protein generates negative Gaussian membrane curvature necessary for budding and scission

The M2 protein is a multi-functional protein, which plays several roles in the replication cycle of the influenza A virus. Here we focus on its ability to promote budding of the mature virus from the cell surface. Using high resolution small angle X-ray scattering we show that M2 can restructure lip...

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Detalhes bibliográficos
Main Authors: Schmidt, Nathan W., Mishra, Abhijit, Wang, Jun, DeGrado, William F., Wong, Gerard C. L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4000230/
https://ncbi.nlm.nih.gov/pubmed/23962302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja400146z
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