Miswiring the brain: Δ(9)-tetrahydrocannabinol disrupts cortical development by inducing an SCG10/stathmin-2 degradation pathway

Children exposed in utero to cannabis present permanent neurobehavioral and cognitive impairments. Psychoactive constituents from Cannabis spp., particularly Δ(9)-tetrahydrocannabinol (THC), bind to cannabinoid receptors in the fetal brain. However, it is unknown whether THC can trigger a cannabinoi...

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Detalhes bibliográficos
Main Authors: Tortoriello, Giuseppe, Morris, Claudia V, Alpar, Alan, Fuzik, Janos, Shirran, Sally L, Calvigioni, Daniela, Keimpema, Erik, Botting, Catherine H, Reinecke, Kirstin, Herdegen, Thomas, Courtney, Michael, Hurd, Yasmin L, Harkany, Tibor
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4000086/
https://ncbi.nlm.nih.gov/pubmed/24469251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/embj.201386035
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