Cyp1a2(-/-) null mutant mice develop normally but show deficient drug metabolism.

Cytochrome P450 1A2 (CYP1A2) is a predominantly hepatic enzyme known to be important in the metabolism of numerous foreign chemicals of pharmacologic, toxicologic, and carcinogenic significance. CYP1A2 substrates include aflatoxin B1, acetaminophen, and a variety of environmental arylamines. To defi...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Liang, H C, Li, H, McKinnon, R A, Duffy, J J, Potter, S S, Puga, A, Nebert, D W
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40000/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8643688/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.4.1671
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