Antagonism of PDGF-BB suppresses subretinal neovascularization and enhances the effects of blocking VEGF-A

Hypoxia-inducible factor-1 (HIF-1) plays an important role in retinal and subretinal neovascularization (NV). Increased levels of HIF-1 cause increased expression of vascular endothelial growth factor (VEGF-A) and current therapies for ocular NV focus on neutralizing VEGF-A, but there is mounting ev...

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Detalhes bibliográficos
Main Authors: Dong, Aling, Seidel, Christopher, Snell, Daniel, Ekawardhani, Savira, Ahlskog, Julia K. J., Baumann, Michael, Shen, Jikui, Iwase, Takeshi, Tian, Jing, Stevens, Rebecca, Hackett, Sean F., Stumpp, Michael T., Campochiaro, Peter A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3999311/
https://ncbi.nlm.nih.gov/pubmed/24154861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10456-013-9402-5
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