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Impaired Geranylgeranyltransferase-I Regulation Reduces Membrane-Associated Rho-Protein Levels in Aged Mouse Brain
Synaptic impairment rather than neuronal loss may be the leading cause of cognitive dysfunction in brain aging. Certain small Rho-GTPases are involved in synaptic plasticity, and their dysfunction is associated with brain aging and neurodegeneration. Rho-GTPases undergo prenylation by attachment of...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3999261/ https://ncbi.nlm.nih.gov/pubmed/24428713 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.12654 |
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