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Global signaling effects of a schizophrenia-associated missense mutation in neuregulin 1: An exploratory study using whole genome and novel kinome approaches
Aberrant Neuregulin 1-ErbB4 signalling has been implicated in schizophrenia. We previously identified a novel schizophrenia-associated missense mutation (valine to leucine) in the NRG1 transmembrane domain. This variant inhibits formation of the NRG1 intracellular domain (ICD) and causes decreases i...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3999257/ https://ncbi.nlm.nih.gov/pubmed/24380930 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00702-013-1142-6 |
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