Fenretinide induces ubiquitin-dependent proteasomal degradation of stearoyl-CoA desaturase in human retinal pigment epithelial cells

Stearoyl-CoA desaturase (SCD, SCD1), an endoplasmic reticulum (ER) resident protein and a rate-limiting enzyme in monounsaturated fatty acid biosynthesis, regulates cellular functions by controlling the ratio of saturated to monounsaturated fatty acids. Increase in SCD expression is strongly implica...

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Detalhes bibliográficos
Main Authors: Samuel, William, Kutty, R. Krishnan, Duncan, Todd, Vijayasarathy, Camasamudram, Kuo, Bryan C., Chapa, Krysten M., Redmond, T. Michael
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3999186/
https://ncbi.nlm.nih.gov/pubmed/24357007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.24527
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