Use of a Synthetic Biosensor for Neutralizing Activity-Biased Selection of Monoclonal Antibodies against Atroxlysin-I, an Hemorrhagic Metalloproteinase from Bothrops atrox Snake Venom

BACKGROUND: The snake Bothrops atrox is responsible for the majority of envenomings in the northern region of South America. Severe local effects, including hemorrhage, which are mainly caused by snake venom metalloproteinases (SVMPs), are not fully neutralized by conventional serum therapy. Little...

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Hlavní autoři: Schneider, Francisco Santos, Nguyen, Dung Le, Castro, Karen Larissa, Cobo, Sandra, Machado de Avila, Ricardo Andrez, Ferreira, Nivia de Assis, Sanchez, Eladio Flores, Nguyen, Christophe, Granier, Claude, Galéa, Pascale, Chávez-Olortegui, Carlos, Molina, Franck
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2014
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3998924/
https://ncbi.nlm.nih.gov/pubmed/24762927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0002826
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