Use of a Synthetic Biosensor for Neutralizing Activity-Biased Selection of Monoclonal Antibodies against Atroxlysin-I, an Hemorrhagic Metalloproteinase from Bothrops atrox Snake Venom

BACKGROUND: The snake Bothrops atrox is responsible for the majority of envenomings in the northern region of South America. Severe local effects, including hemorrhage, which are mainly caused by snake venom metalloproteinases (SVMPs), are not fully neutralized by conventional serum therapy. Little...

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Detalhes bibliográficos
Main Authors: Schneider, Francisco Santos, Nguyen, Dung Le, Castro, Karen Larissa, Cobo, Sandra, Machado de Avila, Ricardo Andrez, Ferreira, Nivia de Assis, Sanchez, Eladio Flores, Nguyen, Christophe, Granier, Claude, Galéa, Pascale, Chávez-Olortegui, Carlos, Molina, Franck
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3998924/
https://ncbi.nlm.nih.gov/pubmed/24762927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0002826
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