ADVANCING AGE IS ASSOCIATED WITH GENE EXPRESSION CHANGES RESEMBLING mTOR INHIBITION: EVIDENCE FROM TWO HUMAN POPULATIONS

Interventions which inhibit TOR activity (including rapamycin and caloric restriction) lead to downstream gene expression changes and increased lifespan in laboratory models. However, the role of mTOR signaling in human aging is unclear. We tested the expression of mTOR-related transcripts in two in...

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Main Authors: Harries, Lorna W, Fellows, Alexander D., Pilling, Luke C., Hernandez, Dena, Singleton, Andrew, Bandinelli, Stefania, Guralnik, Jack, Powell, Jonathan, Ferruci, Luigi, Melzer, David
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3998676/
https://ncbi.nlm.nih.gov/pubmed/22813852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mad.2012.07.003
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