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Microglial Cx3cr1 knockout reduces prion disease incubation time in mice

BACKGROUND: Microglia are resident mononuclear phagocytes of the brain that become activated in response to insults including neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease and prion disease. In the central nervous system the chemokine Cx3cl1 (Fractalkine) is expressed b...

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Main Authors: Grizenkova, Julia, Akhtar, Shaheen, Brandner, Sebastian, Collinge, John, Lloyd, Sarah E
格式: Artigo
語言:Inglês
出版: BioMed Central 2014
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3998043/
https://ncbi.nlm.nih.gov/pubmed/24655482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2202-15-44
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