Identification of BDNF Sensitive Electrophysiological Markers of Synaptic Activity and Their Structural Correlates in Healthy Subjects Using a Genetic Approach Utilizing the Functional BDNF Val66Met Polymorphism

Increasing evidence suggests that synaptic dysfunction is a core pathophysiological hallmark of neurodegenerative disorders. Brain-derived neurotropic factor (BDNF) is key synaptogenic molecule and targeting synaptic repair through modulation of BDNF signalling has been suggested as a potential drug...

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Detalhes bibliográficos
Main Authors: Soltész, Fruzsina, Suckling, John, Lawrence, Phil, Tait, Roger, Ooi, Cinly, Bentley, Graham, Dodds, Chris M., Miller, Sam R., Wille, David R., Byrne, Misha, McHugh, Simon M., Bellgrove, Mark A., Croft, Rodney J., Lu, Bai, Bullmore, Edward T., Nathan, Pradeep J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3997566/
https://ncbi.nlm.nih.gov/pubmed/24760076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0095558
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