Importance of Gradients in Membrane Properties and Electrical Coupling in Sinoatrial Node Pacing

The sinoatrial node (SAN) is heterogeneous in terms of cell size, ion channels, current densities, connexins and electrical coupling. For example, Na(v)1.5 (responsible for I (Na)) and Cx43 (responsible for electrical coupling) are absent from the centre of the SAN (normally the leading pacemaker si...

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Detalhes bibliográficos
Main Authors: Inada, Shin, Zhang, Henggui, Tellez, James O., Shibata, Nitaro, Nakazawa, Kazuo, Kamiya, Kaichiro, Kodama, Itsuo, Mitsui, Kazuyuki, Dobrzynski, Halina, Boyett, Mark R., Honjo, Haruo
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3997424/
https://ncbi.nlm.nih.gov/pubmed/24759974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0094565
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