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The Role of Adenosine Signaling in Sickle Cell Therapeutics

Recent data suggest a role for adenosine signaling in the pathogenesis of sickle cell disease (SCD). Signaling through the adenosine A(2A) receptor (A(2A)R) has demonstrated beneficial effects in SCD. Activation of A(2A)Rs decreases inflammation in mice and patients with SCD largely by blocking acti...

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Bibliografski detalji
Glavni autori: Field, Joshua J., Nathan, David G., Linden, Joel
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3997263/
https://ncbi.nlm.nih.gov/pubmed/24589267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hoc.2013.11.003
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