Pregnanolone Glutamate, a Novel Use-Dependent NMDA Receptor Inhibitor, Exerts Antidepressant-Like Properties in Animal Models

A number of studies demonstrated a rapid onset of an antidepressant effect of non-competitive N-methyl-d-aspartic acid receptor (NMDAR) antagonists. Nonetheless, its therapeutic potential is rather limited, due to a high coincidence of negative side-effects. Therefore, the challenge seems to be in t...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Holubova, Kristina, Nekovarova, Tereza, Pistovcakova, Jana, Sulcova, Alexandra, Stuchlík, Ales, Vales, Karel
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2014
Pynciau:
Neuroscience
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3997017/
https://ncbi.nlm.nih.gov/pubmed/24795582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnbeh.2014.00130
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